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An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis
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How microbial proteomics got started.

Frederick C Neidhardt1

  • 1Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA. fcneid@umich.edu

Proteomics
|May 7, 2011
PubMed
Summary

The 1975 development of two-dimensional gel electrophoresis by Patrick O'Farrell revolutionized proteomics. This foundational technique enabled the study of cellular physiology and microbial proteomics.

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