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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

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Related Experiment Video

Updated: Jun 2, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Cutaneous amyloidosis.

Jessica Borowicz1, Michelle Gillespie, Richard Miller

  • 1Department of Dermatology, Largo Medical Center, Largo, FL, USA. drjflowers@hotmail.com

Skinmed
|May 10, 2011
PubMed
Summary
This summary is machine-generated.

Nodular cutaneous amyloidosis, a rare form of amyloidosis, presents as crusted nodules. While systemic progression is uncommon (<10%), diagnosis requires thorough workup, and effective treatments remain elusive, with local recurrence being frequent.

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Performing and Processing FNA of Anterior Fat Pad for Amyloid
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Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

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Last Updated: Jun 2, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Amyloidosis encompasses systemic and cutaneous forms, including primary, secondary, heredofamilial, and hemodialysis-associated types.
  • Nodular cutaneous amyloidosis is the rarest subtype of primary cutaneous amyloidosis, characterized by immunoglobulin-derived amyloid fibrils (kappa or lambda light chains).
  • Lesions typically manifest as crusted nodules on facial, extremity, or acral sites, potentially linked to a local plasma cell clone or cutaneous plasmacytoma.

Purpose of the Study:

  • To summarize the characteristics, diagnostic workup, and management challenges of nodular cutaneous amyloidosis.
  • To highlight the low risk of systemic progression in nodular cutaneous amyloidosis.
  • To emphasize the difficulties in treating nodular cutaneous amyloidosis and its propensity for local recurrence.

Main Methods:

  • Review of existing literature and case reports on nodular cutaneous amyloidosis.
  • Description of typical clinical presentation and histopathological findings.
  • Outline of recommended diagnostic procedures, including biopsies and serum/urine protein electrophoresis.

Main Results:

  • Nodular cutaneous amyloidosis presents as localized crusted nodules, with amyloid fibrils derived from immunoglobulin light chains.
  • Systemic progression risk is reported to be less than 10%.
  • Diagnostic workup involves physical examination, protein electrophoresis, and biopsies to exclude extracutaneous involvement.

Conclusions:

  • Management of nodular cutaneous amyloidosis is challenging due to a lack of consistently effective treatments.
  • Local recurrence is common, necessitating ongoing monitoring and management.
  • Early and thorough diagnostic evaluation is crucial to rule out systemic involvement.