Related Experiment Video
Updated: Jun 2, 2026
08:57
Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Cellular neurothekeoma with neuroendocrine differentiation
Antonio D'Antonio1, Roberto Cuomo, Basilio Angrisani
1Unit of Pathologic Anatomy and Oncology, A.O. San Giovanni di Dio e Ruggi d'Aragona, via S. Leonardo, Salerno, Italy. ada66@inwind.it
Dermatology Online Journal
|May 10, 2011
Summary
This study details a rare cellular neurothekeoma case with unusual neuroendocrine marker expression. The findings highlight potential diagnostic challenges and suggest divergent differentiation in this tumor type.
Area of Science:
- Oncology
- Pathology
- Immunohistochemistry
Background:
- Cellular neurothekeoma is a rare soft tissue tumor.
- Accurate diagnosis can be challenging due to overlapping features with other mesenchymal neoplasms.
Observation:
- A case of cellular neurothekeoma presented with atypical histopathological features, including nuclear atypia and extension into surrounding tissues.
- Immunohistochemistry revealed neoplastic cells immunoreactive for NKI/C3, CD68, CD10, and smooth-muscle actin, with negative S100 and HMB-45 staining.
- Notably, tumor cells exhibited strong expression of various neuroendocrine markers.
Findings:
- The tumor displayed a micronodular architecture with hypercellular lobules.
- Despite positive margins, no local recurrence was observed after five months of clinical follow-up.
- The immunohistochemical profile, particularly the neuroendocrine marker expression, suggests potential divergent differentiation.
Implications:
- Atypical features necessitate careful differential diagnosis, considering malignant mesenchymal, melanocytic, and fibrohistiocytic tumors.
- The expression of neuroendocrine markers may indicate an origin from myofibroblast and neuroendocrine cells.
- This case expands the understanding of cellular neurothekeoma's diverse immunohistochemical profile and behavior.
