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Daptomycin: evaluation of a high-dose treatment strategy
Gary Wu1, Teena Abraham, Jonathan Rapp
1New York Methodist Hospital, Department of Pharmacy, Brooklyn, NY 11215, USA. gary.wu2@gmail.com
High-dose daptomycin (a lipopeptide antibiotic) is safe and effective for treating infections, even with prolonged use. This approach may also reduce antibiotic resistance and speed up bacterial killing.
Area of Science:
- Pharmacology
- Infectious Diseases
- Microbiology
Background:
- Declining antibiotic pipeline and rising antibacterial resistance necessitate optimizing existing antibiotics.
- Daptomycin, a lipopeptide antibiotic, shows concentration-dependent activity.
- Current dosing for daptomycin is established for specific infections, but higher doses are being explored.
Purpose of the Study:
- To critically evaluate the safety and efficacy of high-dose daptomycin.
- To assess the potential benefits of higher daptomycin dosages in combating bacterial infections.
Main Methods:
- Comprehensive literature review of published data from 1967-2011.
- Inclusion of prospective trials, retrospective reviews, case reports, and in vitro simulation studies.
- MEDLINE search and manual reference checking.
Main Results:
- High-dose daptomycin demonstrated safety and tolerability in clinical trials, retrospective reviews, case reports, and in vitro models.
- Prolonged administration of high-dose daptomycin was well-tolerated.
- In vitro studies indicated that high doses suppress daptomycin resistance emergence and enhance bactericidal activity.
Conclusions:
- High-dose daptomycin is a safe and tolerable option for treating infections.
- This dosing strategy shows promise in enhancing treatment efficacy and combating antibiotic resistance.
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