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Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells

Matthew J Kesic1, Steven O Simmons, Rebecca Bauer

  • 1Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7127, USA. kesic@email.unc.edu

Free Radical Biology & Medicine
|May 10, 2011
PubMed
Summary

The antioxidant pathway Nrf2 (Nuclear factor erythroid 2-related factor 2) significantly impacts influenza virus replication. Activating Nrf2 with antioxidants like SFN and EGCG inhibits viral entry and replication in human nasal cells.

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