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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Updated: Jun 2, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

Smoking and asthma.

Megan Stapleton1, Amanda Howard-Thompson, Christa George

  • 1Department of Clinical Pharmacy, Texas Tech University Health Science Center, Dallas, USA.

Journal of the American Board of Family Medicine : JABFM
|May 10, 2011
PubMed
Summary
This summary is machine-generated.

Smoking and secondhand smoke (SHS) worsen asthma control and reduce the effectiveness of inhaled corticosteroid therapy in asthmatic patients. These exposures negatively impact patient outcomes and treatment response.

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Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
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10:47

Isolation of Mouse Respiratory Epithelial Cells and Exposure to Experimental Cigarette Smoke at Air Liquid Interface

Published on: February 21, 2011

Area of Science:

  • Pulmonology
  • Environmental Health
  • Pharmacology

Background:

  • Asthma prevalence and severity are influenced by environmental factors.
  • Cigarette smoking and secondhand smoke (SHS) exposure are significant concerns for individuals with asthma.

Purpose of the Study:

  • To review the current understanding of smoking and SHS prevalence in asthmatics.
  • To evaluate the adverse effects of smoking and SHS on asthma patient outcomes.
  • To assess the impact on response to inhaled corticosteroids.

Main Methods:

  • Comprehensive literature search of PubMed, Embase, and Scopus.
  • Keywords included "smoking and asthma," "secondhand smoke and asthma," and related terms.
  • Reference lists of identified articles were also reviewed.

Main Results:

  • Asthmatic smokers exhibit poorer disease control compared to non-smokers.
  • Maternal SHS exposure significantly increases asthma frequency, severity, and decreases lung function.
  • Smoking increases airway permeability and decreases histone deacetylase activity, leading to corticosteroid resistance.

Conclusions:

  • Cigarette smoking and SHS exposure have detrimental effects on asthma patient outcomes.
  • These exposures significantly impair the effectiveness of inhaled corticosteroid therapy in asthmatics.