Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

Published on: May 8, 2020

THE IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 IN RATS RECEIVING HETEROTOPIC CARDIAC ALLOGRAFTS.

P Lee¹, N Murase, S Todo

¹Department of Surgery, 3601 Fifth Avenue, Falk Clinic 4 West, Pittsburgh, Pennsylvania 15213.

Surgical Research Communications

|May 10, 2011

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of OKT3 Therapy on Cytomegalovirus and Herpes Simplex Virus Infections After Liver Transplantation.

Transplantation proceedings·2012

Same author

Rapid Flush Technique for Donor Hepatectomy: Safety and Efficacy of an Improved Method of Liver Recovery for Transplantation.

Transplantation proceedings·2011

Same author

Establishment of Primary Cultures of Human Biliary Epithelium and Induction of Class II Major Histocompatibility Complex Antigens by Interferon Gamma.

Transplantation proceedings·2011

Same authorSame journal

IMMUNOSUPPRESSION WITH FR 900506 FOR CANINE KIDNEY AND LIVER TRANSPLANTATION.

Surgical research communications·2011

Same authorSame journal

IN VITRO IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 ON HUMAN T LYMPHOCYTE ALLOACTIVATION.

Surgical research communications·2011

Same author

In Vitro Immunosuppressive Effects of FK506 in Combination With Other Drugs.

Transplantation proceedings·2011

FR 900506 demonstrated immunosuppressive effects in rat heart transplants. Higher doses and specific timing protocols led to significantly extended graft survival, indicating therapeutic potential.

Area of Science:

Immunology
Transplantation Biology
Pharmacology

Background:

Organ transplantation is limited by immune rejection.
Immunosuppressive drugs are crucial for preventing graft rejection.
FR 900506 is a novel immunosuppressive agent.

Purpose of the Study:

To evaluate the immunosuppressive effects of FR 900506.
To determine the efficacy of FR 900506 in preventing heart allograft rejection in rats.

Main Methods:

Lewis rats received ACI heterotopic heart allografts.
Intramuscular administration of FR 900506 at varying doses and schedules.
Graft survival and function were monitored.

Main Results:

More Related Videos

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Related Experiment Videos

Last Updated: Jun 2, 2026

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

Published on: May 8, 2020

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Low doses (0.02 mg/kg) for 2 weeks showed slight graft survival extension.

Higher doses (up to 1.28 mg/kg) for 2 weeks resulted in long-term graft survival.

A short, delayed treatment course (3 doses starting day 4) achieved nearly 3 months of graft survival in 4/6 animals.

Conclusions:

FR 900506 exhibits potent immunosuppressive activity in a heart allograft model.
Dose and treatment timing significantly influence the efficacy of FR 900506.
FR 900506 shows promise as an immunosuppressant for transplantation.