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Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging
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Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging

Jae Hong Lee1, Ju-Hoon So, Jong Hyun Jeon

  • 1Bioorganic Division, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.

Chemical Communications (Cambridge, England)
|May 10, 2011
PubMed

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Labeling DNA Probes03:31

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...