Related Experiment Video
Updated: Jun 2, 2026

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
Published on: June 25, 2017
Changes in glucose-transport associated with malignant transformation (review)
Abstract:
It has been known for many years that changes in glucose metabolism are associated with neoplasia and research on this phenomenon has focused on the enhancement of glucose transport by malignant transformation. Viral transformation of fibroblastic cells provided the first system in which this enhancement could be studied using non-metabolizable glucose analogs. Kinetic and immunological analyses demonstrated that this was due to an increase in the number of glucose carriers at the plasma membrane. In the last 10 years glucose transporter (GLUT) proteins have been characterized by molecular cloning allowing direct examination of the molecular mechanisms of induction of transporter expression. GLUT proteins are a family of at least six separate isoforms which are encoded by distinct genes and differ in tissue distribution and regulation. Two of these isoforms, GLUT1 and GLUT3, are responsible for the changes associated with malignant transformation. The processes involved in the disregulation of these isoforms in the transformation of cultured fibroblastic and hematopoietic cells are described. Analysis of clinical samples indicates that GLUT1 and GLUT3 are often overexpressed in malignant tissue where they may aid tumor growth.
More Related Videos
Related Concept Videos
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Secondary Active Transport
Secondary Active Transport
Glucose Absorption Into the Small Intestine
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

