Mxt mammary-tumor treatment with a high-temperature radiofrequency ablation device

A special catheter with a deploying needle was used to treat MXT mouse mammary tumors transplanted onto the flanks of B6D2F1 mice. The catheter was connected to a radiofrequency generator. Treatment was applied for five minutes, with central tumor temperatures reaching over 100 degrees C. Histopathological examination revealed extensive localized, reproducible and controlled necrosis of the tumors in animals sacrificed at days 5 and 15 after treatment. The effectiveness of this device against MXT tumor growth was enhanced when a combination of radiofrequency and intraperitoneal chemotherapy (9 injections of adriamycin, etoposide and cyclophosphamide) was administered. This study demonstrates the effectiveness and reproducibility of tumor destruction and the increase in effectiveness of chemotherapy effects by radiofrequency heating.