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Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Microencapsulation of bioactive nanoparticles.

Fei Gao1, Ping Wang, Guanghui Ma

  • 1National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

Methods in Molecular Biology (Clifton, N.J.)
|May 10, 2011
PubMed
Summary
This summary is machine-generated.

Researchers developed cell-like microreactors (CLMRs) to overcome nanoparticle catalyst limitations. These microcapsules enable easy handling and recycling of nano-biocatalysts while maintaining high activity.

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Area of Science:

  • Biocatalysis
  • Nanotechnology
  • Chemical Engineering

Background:

  • Enzyme nanoparticles offer enhanced activity and stability but are difficult to recycle and pose environmental risks due to their small size.
  • Current methods for utilizing nanoparticle-based biocatalysts face challenges in practical application and environmental management.

Purpose of the Study:

  • To develop a novel method for preparing microcapsules capable of encapsulating nanoparticle-based biocatalysts.
  • To create cell-like microreactors (CLMRs) that facilitate the handling and recycling of nano-biocatalysts while preserving their activity.

Main Methods:

  • Preparation of single-cavity microcapsules with nano-pores in the shell.
  • Encapsulation of nanoparticle-based biocatalysts within these microcapsules to form CLMRs.

Main Results:

  • The developed microcapsules successfully encaged nanoparticle-based biocatalysts.
  • The encapsulated nano-biocatalysts within the CLMRs maintained high catalytic activities, comparable to those in bulk-phase solutions.
  • The CLMRs, being hundreds-fold larger than the nanoparticles, allowed for significantly easier handling and recycling.

Conclusions:

  • Cell-like microreactors (CLMRs) offer a viable solution for overcoming the limitations of nanoparticle-based biocatalysts.
  • This approach enhances the practical applicability and environmental sustainability of nano-biocatalysts through improved handling and recyclability.