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Updated: Jun 2, 2026

Quantification of Ethanol Levels in Zebrafish Embryos Using Head Space Gas Chromatography
Published on: February 11, 2020
Commentary: will analyzing the epigenome yield cohesive principles of ethanol teratology?
1Department of Neuroscience & Experimental Therapeutics, Texas A&M Health Science Center (RCM), College of Medicine, College Station, TX, USA.
Abstract:
This commentary discusses the impact of the manuscript by Zhou et al., titled "Alcohol Alters DNA Methylation Patterns and Inhibits Neural Stem Cell Differentiation," published in the April 2011 issue of Alcoholism: Clinical and Experimental Research (volume 35, issue 4, pages 1-12). In this manuscript, the authors present intriguing evidence from a genome scale analysis of promoter DNA methylation patterns in a class of neural crest stem cells associated with dorsal root ganglia, showing that ethanol essentially prevents epigenetic programming associated with neural stem cell differentiation. This manuscript presents several interesting and novel pieces of data and raises important questions for future research. The implications of these data for our understanding of the etiology of fetal alcohol spectrum disorders are discussed.
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