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AOM in children
Roger A J M Damoiseaux1, Maroeska M Rovers
1General Practice de Hof van Blom, Hattem, The Netherlands.
Insights
Acute otitis media (AOM) in children often resolves without antibiotics. This review examines treatments and preventive strategies for AOM, evaluating effectiveness and safety to guide clinical decisions.
Area of Science:
- Pediatrics
- Infectious Diseases
- Evidence-Based Medicine
Background:
- Acute otitis media (AOM) is a common childhood illness, frequently treated with antibiotics.
- High antibiotic prescription rates for AOM exist despite spontaneous resolution in many cases.
- AOM is a leading cause for antibiotic use in outpatient pediatric care.
Purpose of the Study:
- To systematically review the effects of various treatments for AOM in children.
- To evaluate interventions aimed at preventing recurrent AOM.
- To synthesize evidence on the effectiveness and safety of AOM management strategies.
Main Methods:
- Conducted a systematic review of medical literature up to September 2010.
- Searched major databases including Medline, Embase, and The Cochrane Library.
- Included data from systematic reviews, RCTs, observational studies, and harms alerts.
Main Results:
- Included 29 systematic reviews, RCTs, or observational studies.
- Performed GRADE evaluation to assess the quality of evidence for interventions.
- Synthesized findings on a range of AOM interventions.
Conclusions:
- The review presents information on the effectiveness and safety of multiple AOM interventions.
- Interventions evaluated include analgesics, antibiotics (immediate, delayed, prophylaxis, longer courses), myringotomy, vaccinations, and xylitol.
- Findings aim to inform clinical practice regarding AOM management and prevention in children.
Introduction:
In the UK, about 30% of children under 3 years of age visit their GP each year with acute otitis media (AOM), and 97% of these receive antibiotics. In the US, AOM is the most common reason for outpatient antibiotic treatment. Without antibiotics, AOM resolves within 24 hours in about 60% of children, and within 3 days in about 80% of children.
Methods And Outcomes:
We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments for AOM in children; and what are the effects of interventions to prevent recurrence? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2010 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
Results:
We found 29 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
Conclusions:
In this systematic review we present information relating to the effectiveness and safety of the following interventions: analgesics, antibiotics, delayed antibiotics, immediate antibiotics, long-term antibiotic prophylaxis, longer courses of antibiotics, myringotomy, pneumococcal vaccination, tympanostomy with ventilation tubes, xylitol syrup or gum, and influenza vaccination.
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