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Related Concept Videos

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance (Clcr), a...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...

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Related Experiment Video

Updated: Jun 2, 2026

Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model
06:04

Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model

Published on: June 9, 2023

Setting the speed limit: a pilot study of the rate of serum creatinine decrease after endoscopic valve ablation in

A V Deshpande1, B S Alsaywid, G H H Smith

  • 1Department of Urology and Centre for Kidney Research, Children's Hospital at Westmead and University of Sydney, Sydney, NSW 2145, Australia.

The Journal of Urology
|May 11, 2011
PubMed
Summary
This summary is machine-generated.

In neonates with posterior urethral valve, serum creatinine decreases significantly within two months after treatment. This rapid decline suggests successful obstruction relief and aids in monitoring kidney function recovery.

Related Experiment Videos

Last Updated: Jun 2, 2026

Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model
06:04

Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model

Published on: June 9, 2023

Area of Science:

  • Pediatric Nephrology
  • Neonatal Surgery
  • Urology

Background:

  • Posterior urethral valve (PUV) is a common cause of bladder outlet obstruction in male neonates.
  • Elevated serum creatinine in neonates with PUV indicates renal dysfunction.
  • Urinary diversion is considered if serum creatinine remains high post-obstruction relief, but optimal recovery rates are undefined.

Purpose of the Study:

  • To define the optimal rate of serum creatinine decrease in neonates following posterior urethral valve ablation.
  • To establish a prediction curve for serum creatinine decline to assess treatment efficacy.

Main Methods:

  • Retrospective review of 15 neonates treated for posterior urethral valve between 2002-2007.
  • Exclusion of 11 patients with delayed diagnosis.
  • Analysis of serial serum creatinine levels to determine the rate of decrease and time to nadir post-valve ablation.

Main Results:

  • Serum creatinine nadir was reached around 6 months of age.
  • 73% of total creatinine decrease occurred within the first 2 months post-ablation (45% reduction from peak).
  • The rate of creatinine decrease was not influenced by initial peak values; outliers included neonates with normal peak creatinine or complications.

Conclusions:

  • The rate of serum creatinine decline in early infancy provides valuable insight into the effectiveness of posterior urethral valve ablation.
  • Monitoring creatinine decrease can help assess the adequacy of surgical intervention and guide further management.