Related Experiment Video
Updated: Jun 2, 2026

09:18
Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
Behavioral response to pain in drowsy and sleeping neonates: a randomized control study
Sheila S Mathai1, Amit Naresh, Sathyajit Sahu
1INHS Asvini (Naval Hospital), Colaba, Mumbai, India. sheilamathai@yahoo.com
Indian Pediatrics
|May 11, 2011
Summary
Newborns who are drowsy or sleeping during a heel prick show a less intense pain response. This study found lower pain scores and shorter crying duration in sleeping infants compared to awake ones.
Area of Science:
- Neonatal care
- Pediatric pain management
- Infant behavior
Background:
- Heel prick procedures are common for newborn screening.
- Assessing pain in neonates is crucial for appropriate care.
- Pain perception and response can vary based on infant state.
Purpose of the Study:
- To investigate the impact of neonatal state (drowsy/sleeping vs. awake) on pain response during heel prick.
- To compare pain scores and crying duration between different infant states.
Main Methods:
- A randomized controlled trial involving 100 healthy term neonates.
- Infants were assigned to either a drowsy/sleeping state or an awake state during heel prick.
- The Neonatal Infant Pain Score (NIPS) and cry duration were measured.
Main Results:
- Infants in the drowsy/sleeping state had significantly lower NIPS scores at 30 seconds post-stimulus (median 5 vs. 6).
- The duration of crying was shorter in the drowsy/sleeping group (29.17 sec vs. 32.67 sec).
- No significant difference in NIPS scores was observed at 45 seconds post-stimulus.
Conclusions:
- Neonatal state significantly influences behavioral pain responses to heel prick.
- Drowsy or sleeping infants exhibit a reduced behavioral response to painful stimuli.
- Optimizing infant state may be a strategy to minimize pain during neonatal procedures.

