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Updated: Jun 2, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
A phase-ii study testing weekly platinum derivative combination chemotherapy as 2nd-line treatment in patients with
J Sculier1, J Thiriaux, G Bureau
1HOP CIVIL CHARLEROI,CHARLEROI,BELGIUM. GRP MED ST REMI,REIMS,FRANCE. HOP A CALMETTE,LILLE,FRANCE. HOP AMBROISE PARE,MONS,BELGIUM. CHU ANDRE VESALE,MONTIGNIES TILLEUL,BELGIUM. HOP HAYANGE,HAYANGE,FRANCE. ACAD ZIEKENHUIS MIDDELHEIM,ANTWERP,BELGIUM. CLIN LOUIS CATY,BAUDOUR,BELGIUM. CLIN LOUVIERE,LILLE,FRANCE. IMC MUTUALIT SOCIALISTES,TOURNAI,BELGIUM. LUNGENKLIN HECKESHORN,BERLIN,GERMANY.
Abstract:
A phase II trial was conducted to determine the effectiveness of weekly administration of cisplatin (25 mg/m(2) on day 1) and carboplatin (100 mg/m(2) on day 1) as salvage chemotherapy for patients with small cell lung cancer after first-line chemotherapy without platinum derivatives. Of 40 eligible patients, 38 were evaluable for response. Interval between last course of first-line chemotherapy and first course of salvage therapy was less than 3 months in 34 and greater in 4. Five partial responses (13%; confidence interval at 95%:0.01-0.25) were documented (including 4 in patients with a treatment-free interval <3 months) as well as 8 no change, 21 progressions and 4 early deaths due to malignant disease. Toxicity consisted mainly of moderate thrombopenia and leucopenia. Grade I nephrotoxicity was observed in 6 patients. In conclusion, weekly administration of moderate doses of cisplatin and carboplatin as salvage chemotherapy for small cell lung cancer appeared feasible and was associated with a moderate but definitive anticancer activity.
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