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Updated: Jun 2, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
Published on: May 31, 2017
Cell replacement therapies for nervous system regeneration.
Guillermina López-Bendito1, Paola Arlotta
1Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), San Joan d'Alacant, 03550, Spain. g.lbendito@umh.es
The adult brain exhibits greater plasticity than previously believed, with new neuron growth occurring even in humans. Research explores enhancing central nervous system (CNS) repair for neurodegenerative disorders and injuries.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Developmental Biology
Background:
- Historically, the adult brain was viewed as a declining organ.
- Recent discoveries reveal significant brain plasticity, including adult neurogenesis.
- Limited endogenous repair capacity in the central nervous system (CNS) necessitates novel therapeutic strategies.
Purpose of the Study:
- To explore barriers to neuronal regeneration in the CNS.
- To develop novel approaches for neuronal and circuit repair.
- To understand the therapeutic potential of manipulating neural progenitors, differentiated cells, and pluripotent stem cells.
Main Methods:
- A scientific assembly focused on central nervous system (CNS) regeneration.
- Discussion integrated perspectives on developmental and adult neurogenesis.
- Exploration of strategies for manipulating neural stem cells and other cell types.
Main Results:
- The adult brain possesses greater plasticity than previously assumed.
- Adult neurogenesis occurs in specific brain regions in humans.
- An integrated view of neurogenesis informs potential therapeutic interventions.
Conclusions:
- Understanding neurogenesis is key to unlocking CNS repair.
- Manipulation of neural progenitors and stem cells offers therapeutic promise.
- New insights into brain plasticity may overcome limitations in treating neurodegenerative disorders and injuries.
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08:52Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
Published on: January 10, 2018
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