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Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)
Published on: April 23, 2015
Technical approaches for mouse models of human disease.
Monica J Justice1, Linda D Siracusa, A Francis Stewart
1Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. mjustice@bcm.edu
Disease Models & Mechanisms
|May 12, 2011
Summary
Mice offer extensive genetic diversity and genome manipulation tools for disease research. These methods, including natural variation and genetic engineering, are crucial for modeling human diseases and understanding population diversity.
Area of Science:
- Genetics and Genomics
- Disease Modeling
- Mammalian Research
Background:
- Mice are a primary model organism in disease research.
- Natural genetic variations exist in various mouse strains.
- Spontaneous mutations contribute to genetic diversity.
Purpose of the Study:
- To review major genome manipulation techniques in mice for human disease research.
- To highlight the mouse's unique suitability for genetic studies.
- To connect mouse genetic diversity to human population diversity.
Main Methods:
- Utilizing natural genetic variation in mouse strains.
- Employing targeted mutations to eliminate gene function.
- Conducting forward genetic screens with chemicals or transposons.
- Introducing exogenous transgenes, DNA, bacterial artificial chromosomes (BACs), or reporter constructs.
- Leveraging reverse genetics, transgenics, and transposon technology.
Main Results:
- Mice provide a rich resource of genetic diversity.
- Extensive genome manipulation is possible in mice.
- Various techniques allow for precise genetic modifications.
- These manipulations are powerful tools for modeling human diseases.
Conclusions:
- Mice are uniquely suited for modeling human diseases due to their genetic diversity and manipulability.
- Genome manipulation techniques in mice are essential for understanding human disease.
- Studying mouse genetic diversity aids in understanding human population diversity.
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