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Related Concept Videos

Integrins01:10

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

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An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells
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Published on: August 13, 2021

Netrins: versatile extracellular cues with diverse functions.

Karen Lai Wing Sun1, James P Correia, Timothy E Kennedy

  • 1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.

Development (Cambridge, England)
|May 12, 2011
PubMed
Summary
This summary is machine-generated.

Netrins are secreted proteins crucial for guiding cell and axon migration in neural development. They also regulate the formation and organization of various tissues throughout life.

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Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System
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Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System

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Last Updated: Jun 2, 2026

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Published on: August 13, 2021

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04:47

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Published on: May 22, 2020

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Background:

  • Netrins are secreted proteins initially identified as guidance cues for neural development.
  • Their roles extend beyond the nervous system, influencing vasculature, lung, pancreas, muscle, and mammary gland formation.
  • Netrins and their receptors are vital for maintaining tissue organization in mature organisms.

Purpose of the Study:

  • To review the mechanisms of netrin signaling in both vertebrate and invertebrate systems.
  • To discuss the diverse functions of netrin signaling in neural and non-neural tissue development.

Main Methods:

  • Literature review of existing research on netrin signaling.
  • Analysis of studies detailing netrin functions in development and tissue maintenance.

Main Results:

  • Netrins mediate cell migration, cell-cell interactions, and cell-extracellular matrix adhesion.
  • Netrin signaling is essential for the development of various organ systems.
  • Ongoing netrin expression is critical for maintaining tissue organization.

Conclusions:

  • Netrin signaling is a fundamental process with broad implications in developmental biology.
  • Understanding netrin functions provides insights into tissue formation and maintenance across species.