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Related Experiment Videos

Is the corpus luteum normal after ovulation induction?

S Lenz1, S Lindenberg

  • 1Department of Obstetrics and Gynecology, Rigshospitalet, University of Copenhagen, Denmark.

Journal of Clinical Ultrasound : JCU
|March 1, 1990
PubMed
Summary

Fertility treatments using clomiphene citrate and human menopausal gonadotropin stimulate multiple follicle development. However, stimulated cycles show a higher incidence of persistent follicles, raising questions about corpus luteum function.

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A multi-centre phase 3 study comparing efficacy and safety of Bemfola(®) versus Gonal-f(®) in women undergoing ovarian stimulation for IVF.

Reproductive biomedicine online·2015

Area of Science:

  • Reproductive Endocrinology
  • Medical Imaging

Background:

  • Assessing ovarian response to ovulation induction is crucial for fertility treatments.
  • Monitoring follicle development and luteal phase function requires precise methods.

Purpose of the Study:

  • To compare ultrasound and hormonal profiles in normal versus stimulated ovarian cycles.
  • To investigate the occurrence of persistent follicles after ovulation induction with CC/hMG.

Main Methods:

  • Ultrasound examinations and serial blood sampling for estradiol, progesterone, and LH.
  • Administration of hCG to trigger ovulation in stimulated cycles.
  • Hormonal analysis to confirm ovulation and luteal phase normalcy.

Main Results:

Related Experiment Videos

  • Stimulated cycles (CC/hMG) yielded an average of 4.1 follicles (≥15 mm) compared to one in normal cycles.
  • Persistent follicles were observed in 42% of stimulated cycles versus 7% in normal cycles.
  • Midluteal phase ultrasound revealed varied echogenic structures at former follicle sites in both groups.

    • Conclusions:

    • Ovulation induction with CC/hMG leads to significantly more persistent follicles.
    • The high rate of persistent follicles warrants further investigation into potential compromised corpus luteum function despite normal hormonal profiles.