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Updated: Jun 2, 2026

A New Screening Method for the Directed Evolution of Thermostable Bacteriolytic Enzymes
13:30

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Published on: November 7, 2012

Dramatically improved catalytic activity of an artificial (S)-selective arylmalonate decarboxylase by

Yusuke Miyauchi1, Robert Kourist, Daisuke Uemura

  • 1Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa, 223-8522, Japan.

Chemical Communications (Cambridge, England)
|May 12, 2011
PubMed
Summary

Structure-guided directed evolution significantly enhanced arylmalonate decarboxylase activity. This resulted in a 220-fold increase in (S)-naproxen production with high enantioselectivity.

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