6q(-) as the only cytogenetic aberration - loss of 6q23 and survival in hematologic malignancies
Related Experiment Video
Updated: Jun 2, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
B Pedersen1, S Hammoudah, P Jensen
1AARHUS UNIV,AARHUS KOMMUNE HOSP,DEPT HEMATOL & MED,DK-8000 AARHUS,DENMARK.
Abstract:
Deletion of a segment of the long arm of chromosome 6 (6q-) is relatively frequent in lymphoid leukemias and malignant lymphomas, but rare in myeloid leukemias and myelodysplastic syndromes. The possible clinical consequences of 6q deletions are unknown. We hav approached this problem by looking for relations between loss of 6q bands and clinical as well as hematological parameters in patients with hematological malignancies. We found that survival was significantly shorter and the 6-q-metaphase prevalences significantly higher when 6q23 had been deleted. No other 6q band showed non-random associations. A candidate tumor suppressor gene may be encoded in 6q23.
Related Concept Videos
Karyotyping
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancers Originate from Somatic Mutations in a Single Cell

