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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...

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Updated: Jun 2, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Basic science in Parkinson's disease: its impact on clinical practice.

Jörg B Schulz1, Manfred Gerlach, Gabriele Gille

  • 1Department of Neurology, University Hospital, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany. jschulz@ukaachen.de

Journal of Neurology
|May 12, 2011
PubMed
Summary

Basic science has significantly advanced Parkinson's disease (PD) treatment, offering numerous therapies today. Continued research, particularly in early diagnosis, is crucial for developing future disease-modifying treatments.

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Genetics

Background:

  • Clinical trials for Parkinson's disease (PD) treatments have faced challenges in demonstrating disease modification.
  • This has led to questions about the impact of basic science research on clinical practice for PD.

Purpose of the Study:

  • To review the impact of basic science on current Parkinson's disease (PD) clinical practice.
  • To highlight the role of basic science in understanding PD pathogenesis and developing diagnostic tools.

Main Methods:

  • Literature review of basic science research in Parkinson's disease (PD).
  • Analysis of the translation of genetic and pathogenetic findings into clinical applications.
  • Evaluation of the impact on diagnostic and therapeutic strategies.

Main Results:

  • Basic science has enabled the development of current symptomatic treatments for Parkinson's disease (PD), including dopaminergic, non-dopaminergic, and surgical options.
  • Significant progress in understanding PD neurodegeneration through genetic and biochemical pathway research.

Conclusions:

  • Basic science has been instrumental in transforming Parkinson's disease (PD) from an untreatable condition to one with available therapies.
  • Early and pre-symptomatic diagnosis, driven by basic science, is essential for the future development of disease-modifying treatments for PD.