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[Effect of glucosamine sulfate on the immunological function of normal mice]
Guanmin Chen1, Run Chen, Rongbiao Zhang
1Fujian Center for Disease Control and Prevention, Fuzhou 350001, China. chinacgm@sina.com
Objective:
To observe the effects of glucosamine sulfate on the immunity of normal mice.
Methods:
Female ICR mice were divided by weight into four groups, including low dose group (150 mg x kg(-1)), medium dose group (300 mg x kg(-1)), high dose group (900 mg x kg(-1)) and normal control group. Spleen and thymus were weighted 30 days later, cell mediated immunity, humoral immunity, phagocytosis of mononuclear phagocyte and the activity of NK cell were assayed.
Results:
The thymus index in high dose group was decreased significantly in compared with control group (P < 0.05). Compared with the control group, the delayed type hypersensitivity, serum hemolysin and the ability of antibody production were improved significantly in glucosamine sulfate groups (P < 0.05). The activity of NK cell in high dose group was higher than that of the control group (P < 0.05). The proliferation of spleen lymphocyte, the rate of phagocytosis and the carbon particle clearance index in all glucosamine sulfate groups were similar to those in the control group.
Conclusion:
The immune function of normal mice could be enhanced by glucosamine sulfate, including cellular immunity, humoral immunity and the activity of NK cell.
