Related Experiment Video

Updated: May 22, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

14.5K

Navigating TAM receptor dynamics in tumour immunotherapy

Jihao Yang1, Guanmin Chen1, Rui Wang1

  • 1School of Acupuncture and Tuina, Shandong University of Traditional Chinese, Medicine, Jinan, 250013, People's Republic of China.

Cancer Immunology, Immunotherapy : CII
|March 15, 2025
PubMed

Insights

The TAM receptor family plays a crucial role in tumor immunity by promoting tumor cell survival and immune evasion. Inhibitors targeting these receptors offer promising therapeutic strategies for cancer treatment.

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • The TAM receptor tyrosine kinase family (TAMs) comprises TYRO3, AXL, and MER, which are increasingly recognized for their roles in tumor immunity.
  • TAM receptor activation supports tumor cell survival, proliferation, invasion, and metastasis.
  • TAMs also suppress anti-tumor immune responses, enabling tumor cells to evade immune surveillance.

Purpose of the Study:

  • To review the kinetic characteristics of the TAM receptor family.
  • To elucidate the dual role of TAM receptors in tumor immunity.
  • To analyze downstream signaling pathways and therapeutic strategies involving TAM receptor inhibitors.

Main Methods:

  • Literature review focusing on TAM receptor family kinetics, signaling, and therapeutic targeting.
  • Analysis of preclinical and clinical data on TAM receptor inhibitors.
  • Synthesis of information on combination therapies for cancer treatment.

Main Results:

  • TAM receptors exhibit complex roles, promoting tumor progression and immune suppression.
  • Inhibitors targeting TAM receptors are under active preclinical and clinical development.
  • Various strategies and combination therapies are being explored to modulate tumor immunity via TAM receptors.

Conclusions:

  • Understanding TAM receptor biology is critical for advancing cancer immunotherapy.
  • Targeting TAM receptors presents a promising avenue for novel cancer therapies.
  • Further research into kinetic characteristics and downstream signaling will refine therapeutic strategies.
Keywords:
AXLMERTKTAM receptorTYRO3Tumour

More Related Videos

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

3.3K
Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

6.4K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
457
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.0K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
12.0K