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[Prevention of antibiotic-associated diarrhea in children]

I N Zakharova, Iu A Dmitrieva, O M Goriukhina

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |May 13, 2011
    PubMed

    Insights

    Antibiotic-associated diarrhea, including C. difficile infection, is a common complication. Saccharomyces boulardii probiotics show promise for prevention and treatment.

    Area of Science:

    • Microbiology
    • Gastroenterology
    • Pharmacology

    Background:

    • Antibiotic therapy frequently leads to diarrheal syndromes.
    • These syndromes can stem from direct antibiotic toxicity or disruption of gut flora.
    • Clostridioides difficile infection (CDI) is a significant concern, potentially causing pseudomembranous colitis.

    Purpose of the Study:

    • To review current data on antibiotic-associated diarrhea (AAD).
    • To discuss the prevalence, etiology, and pathogenesis of AAD and CDI.
    • To explore modern prevention and treatment strategies for AAD, including probiotic use.

    Main Methods:

    • Literature review of current data on AAD and CDI.
    • Analysis of etiological and pathogenetic factors.
    • Evaluation of clinical variants of klostridial infections.
    • Assessment of modern therapeutic and prophylactic approaches.

    Main Results:

    • AAD is a frequent complication of antibiotic use.
    • Clostridioides difficile infection is a major cause of severe AAD.
    • Pseudomembranous colitis is a serious consequence of CDI in various age groups.
    • Saccharomyces boulardii is highlighted as a potential therapeutic agent.

    Conclusions:

    • Antibiotic-associated diarrhea and C. difficile infection require careful management.
    • Understanding the etiology and pathogenesis is crucial for effective intervention.
    • Probiotic preparations, specifically Saccharomyces boulardii, offer a promising avenue for prevention and treatment.

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