Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Four-Week Treatment With Dapagliflozin Is Associated With a Reduction in Insulin-Stimulated Renal Cortical Glucose Uptake: A Post Hoc Analysis From a Pilot Study.

Diabetes, obesity & metabolism·2026

Same author

Baseline characteristics of patients enrolled in the AZIMUTH trial: an e-health-integrated, smartphone app-based model of care for heart failure patients.

European heart journal open·2026

Same author

Unlocking the myocardial bridge enigma via precision medicine.

European heart journal·2026

Same author

Real-world presentation of myocardial bridging in the cath-lab: a case series.

European heart journal. Case reports·2026

Same author

Oral Anticoagulation With or Without Antiplatelet Therapy in Chronic Coronary Syndrome: A Meta-Analysis of Randomized Trials.

JACC. Cardiovascular interventions·2026

Same author

Aspirin vs clopidogrel in chronic coronary syndromes: a meta-analysis of ethnic differences.

European heart journal·2026

Same journal

Sparganosis.

The New England journal of medicine·2026

Same journal

Caring for an Aging America - The Looming Crisis of the Long-Term-Care Workforce.

The New England journal of medicine·2026

Same journal

For Those Left Behind.

The New England journal of medicine·2026

Same journal

Colliding Forces - The Aging of the Baby Boom Generation and Contracting Nursing-Home Supply.

The New England journal of medicine·2026

Same journal

Mandated State-Level Surveillance of Assisted Reproductive Technology - An Emerging Threat in the United States.

The New England journal of medicine·2026

Same journal

Ebola at 50 - Lessons for Outbreak Response and Preparedness.

The New England journal of medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 5, 2026

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture

Published on: July 21, 2020

Evidence for human lung stem cells.

Jan Kajstura¹, Marcello Rota, Sean R Hall

¹Department of Anesthesia, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

The New England Journal of Medicine

|May 13, 2011

Summary

This summary is machine-generated.

Human lungs harbor resident stem cells in the distal airways. These cells regenerate damaged lung tissue in animal models, showing potential for treating lung diseases.

More Related Videos

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Engineered Lung Tissues Prepared from Decellularized Lung Slices

Engineered Lung Tissues Prepared from Decellularized Lung Slices

Published on: January 21, 2022

Related Experiment Videos

Last Updated: May 5, 2026

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture

Published on: July 21, 2020

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Engineered Lung Tissues Prepared from Decellularized Lung Slices

Engineered Lung Tissues Prepared from Decellularized Lung Slices

Published on: January 21, 2022

Area of Science:

Pulmonary Medicine
Stem Cell Biology
Regenerative Medicine

Background:

Resident stem cells in the human lung have not been clearly identified.
Previous research described progenitor cells in various lung regions.

Purpose of the Study:

To identify and characterize human lung stem cells.
To evaluate their regenerative potential in vivo.

Main Methods:

Human lung tissue specimens were analyzed in situ.
Phenotype and functional properties were assessed in vitro and in vivo.
Stem cell behavior was studied in serial-transplantation assays.

Main Results:

Undifferentiated human lung stem cells were found in distal airway niches.
These cells demonstrated self-renewal, clonogenicity, and multipotency in vitro.
In vivo, human lung stem cells regenerated functional bronchioles, alveoli, and pulmonary vessels in damaged mouse lungs, forming a chimeric lung.

Conclusions:

Identifiable stem cells exist in the human lung.
These cells contribute to tissue homeostasis and regeneration in animal models.
They hold potential for lung tissue restoration in patients with lung disease.