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Published on: April 21, 2017
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Etiological analysis of presumed perinatal stroke
1Marmara University School of Medicine, Department of Pediatrics, Division of Child Neurology, Istanbul, Turkey. canankocaman@hotmail.com
Brain & Development
|May 13, 2011
Summary
Congenital hemiparesis in infants is often linked to perinatal stroke. This study found that most cases involve prothrombotic risk factors and potential prenatal influences like intrauterine growth retardation.
Area of Science:
- Pediatric Neurology
- Neonatology
- Hematology
Background:
- Congenital hemiparesis is a significant neurological condition in newborns.
- The precise causes of presumed perinatal stroke (PPS) remain incompletely understood.
- Identifying risk factors is crucial for understanding and potentially preventing PPS.
Purpose of the Study:
- To investigate maternal, perinatal, and prothrombotic factors associated with congenital hemiparesis.
- To determine the prevalence of specific prothrombotic risk factors in infants with PPS.
- To explore potential prenatal risk factors contributing to PPS.
Main Methods:
- Retrospective analysis of patients with congenital hemiparesis.
- Assessment of various prothrombotic factors: protein C, protein S, antithrombin III, lipoprotein (a), homocysteine, factor VIII, anticardiolipin antibodies, lupus anticoagulant.
- Genetic testing for methylenetetrahydrofolate reductase (MTHFR) mutations, factor V Leiden, and prothrombin G20210A mutations.
Main Results:
- Arterial ischemic stroke occurred in 60% and periventricular venous infarction in 40% of cases.
- At least one prothrombotic risk factor was identified in 69% of patients.
- The most frequent combination of risk factors was MTHFR C677T and factor V Leiden heterozygosity.
Conclusions:
- A significant proportion of patients with PPS exhibit one or more prothrombotic risk factors.
- Prenatal factors such as intrauterine growth retardation, twin gestation, and preeclampsia may be associated with PPS.
- Further research is needed to elucidate the complex etiology and pathogenesis of PPS.
