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Updated: Jun 2, 2026
07:45
Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
[Epidemiology of urolithiasis]
Michel Daudon1, Bertrand Knebelmann
1Service de biochimie A, hôpital Necker-Enfants malades, AP-HP, université Paris-Descartes, 75743 Paris Cedex 15. miche.daudon@nck.aphp.fr
La Revue Du Praticien
|May 14, 2011
Summary
Calcium oxalate stones plateaued in French males, with rising uric acid stones linked to obesity. Females saw more brushite stones and fewer struvite stones, reflecting lifestyle changes.
Area of Science:
- Nephrology
- Urology
- Epidemiology
Context:
- Trends in kidney stone composition are frequently documented.
- Calcium oxalate nephrolithiasis has shown a consistent increase in industrialized nations.
- Recent French data indicates shifts in stone types over two decades.
Purpose:
- To analyze temporal changes in kidney stone composition in France.
- To correlate these changes with evolving risk factors like diet, lifestyle, and socio-economic status.
Summary:
- In French males, calcium oxalate stones stabilized, with a decline in weddellite subtypes and a rise in uric acid calculi, associated with increased obesity and type 2 diabetes.
- French females exhibited an increase in brushite stones and a decrease in struvite calculi.
- These compositional shifts suggest evolving lithogenic risk factors influenced by population-level changes.
Impact:
- Provides insights into the changing landscape of kidney stone disease in a developed country.
- Highlights the influence of modern lifestyle and metabolic diseases on stone formation.
- Informs public health strategies and clinical management of nephrolithiasis.
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