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Whooping cough in Pakistan: Bordetella pertussis vs Bordetella parapertussis in 2005-2009

Habib Bokhari1, Fahad Said, Muhammad A Syed

  • 1Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan. habib@comsats.edu.pk

Scandinavian Journal of Infectious Diseases
|May 14, 2011
PubMed

Insights

This study found Bordetella parapertussis, not Bordetella pertussis, in most suspected whooping cough cases in Pakistan. Researchers recommend considering vaccines for both Bordetella species.

Area of Science:

  • Microbiology
  • Pediatrics
  • Epidemiology

Background:

  • Pertussis (whooping cough) is a significant respiratory illness in infants and children.
  • It is primarily caused by Bordetella pertussis and Bordetella parapertussis.
  • Understanding the prevalence of different Bordetella species is crucial for effective disease control.

Purpose of the Study:

  • To determine the proportion of Bordetella species causing suspected whooping cough cases.
  • To analyze Bordetella species distribution in Pakistan between 2005 and 2009.

Main Methods:

  • Collection of 802 samples from suspected pertussis cases.
  • Utilized bacterial culture, identification, DNA extraction, and polymerase chain reaction (PCR) with specific gene targets (IS1001, IS1002, IS481).

Main Results:

  • Bordetella parapertussis was identified in 7.4% of isolates.
  • Bordetella pertussis was not detected by culture.
  • PCR detected Bordetella pertussis in a small percentage (0.6%) of cases.

Conclusions:

  • The study highlights the unexpected prevalence of Bordetella parapertussis over Bordetella pertussis in the studied population.
  • Findings suggest the need to evaluate and potentially update vaccination strategies to include protection against both Bordetella species.

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