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Published on: May 3, 2021
CD86 + 1057G/A polymorphism and susceptibility to osteosarcoma.
Wen Wang1, Haihan Song, Jie Liu
1Traumatic Orthopedic Department, General Hospital of Jinan Military Command, Jinan, P.R. China.
DNA and Cell Biology
|May 14, 2011
Summary
The CD86 gene
Area of Science:
- Immunology and Genetics
- Cancer Research
Background:
- CD86 (B7-2) is a costimulatory molecule crucial for immune responses.
- CD86 + 1057G/A polymorphism (rs1129055) has been linked to various diseases.
- Understanding genetic predispositions for osteosarcoma is vital.
Purpose of the Study:
- To examine the association between the CD86 + 1057G/A polymorphism and osteosarcoma risk.
- To investigate this genetic link within a Chinese population.
Main Methods:
- Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used.
- Genotyping was performed on 205 osteosarcoma cases and 216 healthy controls.
Main Results:
- The CD86 + 1057 AA genotype was significantly more frequent in osteosarcoma patients (OR=2.18, p=0.008).
- The +1057 A allele was also elevated in patients (OR=1.43, p=0.011).
Conclusions:
- The CD86 + 1057G/A polymorphism is associated with increased osteosarcoma susceptibility.
- This finding highlights a potential genetic marker for osteosarcoma risk in the studied population.
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