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Rotation thromboelastography (ROTEM) parameters are influenced by age, gender, and oral contraception.

C Sucker1, K Tharra, J Litmathe

  • 1LaboMed Coagulation Centre, Tauentzienstrasse 7, Berlin, Germany. sucker@labomed.de

Perfusion
|May 14, 2011
PubMed
Summary
This summary is machine-generated.

Rotation thromboelastography (ROTEM) requires gender, age, and oral contraception adjustments for accurate hemostasis screening. These factors significantly influence ROTEM parameters in healthy individuals.

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Area of Science:

  • Hematology
  • Clinical Chemistry

Background:

  • Rotation thromboelastography (ROTEM) is a rapid diagnostic tool for hemostatic abnormalities.
  • Establishing accurate reference values is crucial for efficient ROTEM utilization.

Purpose of the Study:

  • To determine the influence of gender, age, and oral contraception on ROTEM parameters.
  • To establish the need for adjusted reference values in ROTEM analysis.

Main Methods:

  • Examined five healthy subject cohorts using ROTEM with extrinsic, intrinsic, or recalcification activation.
  • Cohorts included males (<45 and >45 years), females (<45 years with/without oral contraception), and females (>45 years).

Main Results:

  • Significant variations in ROTEM parameters were observed based on gender.
  • Age was found to significantly impact ROTEM results.
  • Oral contraception use in females demonstrably altered ROTEM parameter values.

Conclusions:

  • Gender, age, and oral contraception significantly affect ROTEM measurements.
  • Adjusted reference ranges for ROTEM are necessary for accurate hemostasis screening.
  • ROTEM analysis requires consideration of demographic factors for clinical interpretation.