Molecular and genetic features of zinc transporters in physiology and pathogenesis

Zinc (Zn) is a vital element. It plays indispensable roles in multifarious cellular processes, affecting the expression and activity of a variety of molecules, including transcription factors, enzymes, adapters, channels, growth factors, and their receptors. A disturbance in Zn homeostasis due to Zn deficiency or an excess of Zn absorption can therefore impair the cellular machinery and exert various influences on physiological programs, such as systemic growth, morphogenetic processes, and immune responses, as well as neuro-sensory and endocrine functions. Thus, Zn imbalance becomes pathogenic in humans. Zn homeostasis is controlled by the coordinated actions of Zn transporters, which are responsible for Zn influx and efflux, and intricately regulate the intracellular and extracellular Zn concentration and distribution. In this review, we describe crucial roles of Zn transporters in biological phenomena, focusing in particular on how Zn transporters contribute to cellular events at the molecular, biochemical, and genetic level, with recent progress uncovering the roles of Zn transporters in physiology and pathogenesis.