Experimental-study of radiofrequency capacitive hyperthermia on transplanted tumor

The in vivo effects of radiofrequency capacitive hyperthermia combined with cis-diammine-dichloroplatinum (CDDP) were studied using nude mice bearing a subcutaneous graft of KK-47 cells derived from human bladder cancer. Tumor growth curve was obtained by measuring the transplanted tumor volume for 21 consecutive days after the treatment. After the treatment, the tumor was removed and examined light-microscopically. Tumor growth was inhibited for 21 days after chemotherapy, hyperthermia, or chemohyperthermia, as compared with the control group. Comparing the chemohyperthermia group with the other groups, it was found that tumor reduction rate was greater in the former group than those in other groups tested. With respect to the combined chemohyperthermic treatment, hyperthermia significantly enhanced the anti-tumor efficacy of CDDP.