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Molecular targets of selenium in prostate cancer prevention (Review)

Rizky Abdulah1, Kenji Kobayashi, Chiho Yamazaki

  • 1Division of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang Km.21, Jatinangor 45363, Indonesia. abdulahrizky@gmail.com

International Journal of Oncology
|May 14, 2011
PubMed

Insights

Selenium shows promise in treating prostate cancer, inhibiting its development through various mechanisms. Further research supports its potential clinical use for this male cancer.

Area of Science:

  • Oncology
  • Nutritional Science
  • Molecular Biology

Background:

  • Prostate cancer is a significant cause of cancer-related mortality in men.
  • Clinical applications of the micronutrient selenium for prostate cancer are currently limited.
  • Emerging evidence suggests selenium's therapeutic potential in prostate cancer management.

Purpose of the Study:

  • To review current epidemiological and biomolecular research on selenium's role in prostate cancer.
  • To evaluate the prospects of selenium for future clinical application in prostate cancer treatment.

Main Methods:

  • Literature review of epidemiological studies.
  • Analysis of biomolecular research on selenium's mechanisms of action.
  • Assessment of clinical trial outcomes and future potential.

Main Results:

  • Selenium demonstrates inhibitory effects on prostate cancer through multiple biological pathways.
  • Existing clinical trial data, though limited, indicates positive outcomes with selenium use.
  • Selenium appears beneficial in controlling the progression of prostate cancer.

Conclusions:

  • Selenium is a promising micronutrient for prostate cancer intervention.
  • Further investigation into selenium's efficacy and safety in clinical settings is warranted.
  • Selenium holds potential for integration into future prostate cancer treatment strategies.

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