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Updated: Jun 2, 2026
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Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping
Published on: June 13, 2025
Diffusion spectral imaging modules correlate with EEG LORETA neuroimaging modules
Robert W Thatcher1, Duane M North, Carl J Biver
1NeuroImaging Laboratory, Applied Neuroscience Research Institute, St. Petersburg, Florida 33722, USA. rwthatcher@yahoo.com
Human Brain Mapping
|May 14, 2011
Summary
Electroencephalography (EEG) temporal correlations align with anatomical modules identified by diffusion spectral imaging (DSI), suggesting EEG reflects synaptic connectivity. This study links brain region temporal dynamics to synaptic density.
Area of Science:
- Neuroscience
- Brain Imaging
- Computational Neuroscience
Background:
- The relationship between functional brain activity and underlying anatomical connectivity is a key area of neuroscience research.
- Electroencephalography (EEG) provides temporal measures of brain activity, while diffusion spectral imaging (DSI) offers insights into structural connectivity.
Purpose of the Study:
- To investigate whether temporal correlations in three-dimensional EEG current source density correspond to anatomical modules with high synaptic connectivity.
- To test the hypothesis linking EEG temporal dynamics to structural synaptic organization.
Main Methods:
- EEG data (eyes closed/open) were recorded from 71 subjects (13-42 years) at 19 scalp locations.
- Low-Resolution Electromagnetic Tomography (LORETA) was computed (1-30 Hz) across cortical voxels, grouped into six anatomical modules based on DSI ROIs.
- Cross-correlations within and between DSI modules were analyzed and compared to EEG current source density correlations.
Main Results:
- The correlation structure observed in anatomical modules from Hagmann et al.'s [2008] DSI study was successfully replicated in the correlation structure of the 3D EEG current source density.
- This indicates a congruence between functional temporal correlations in EEG and structural connectivity patterns.
Conclusions:
- Temporal correlations between brain regions, as measured by EEG, are demonstrably related to synaptic density.
- The findings support the use of EEG in inferring aspects of brain's structural synaptic organization.
