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Updated: Jun 2, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

[Lentigo maligna: a special melanoma].

F-A Le Gal¹, L Toutous-Trellu, G Kaya

¹Clinique de dermatologie HUG, 1211 Geneve.

Revue Medicale Suisse

|May 17, 2011

Summary

Lentigo maligna (LM) and lentigo maligna melanoma (LMM) are increasingly affecting younger individuals and represent 10% of melanomas. Advanced imaging aids diagnosis and surgical planning, with surgery as the primary treatment.

Area of Science:

Dermatology
Oncology
Pathology

Context:

Lentigo maligna (LM) and lentigo maligna melanoma (LMM) constitute approximately 10% of all melanoma cases.
These conditions exhibit unique epidemiological, clinical, histological, and genetic profiles.
There is a concerning trend of these melanomas affecting progressively younger patient populations.

Purpose:

To review the distinct characteristics of LM and LMM.
To highlight advancements in diagnostic imaging for LM and LMM.
To discuss current treatment strategies, including surgery and alternative options.

Summary:

LM and LMM are distinct melanoma subtypes with evolving epidemiology.
Innovations in dermoscopy and in vivo confocal reflectance microscopy enhance diagnostic accuracy and surgical preparation.

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Surgical excision remains the gold standard treatment, with considerations for alternative therapies in specific patient groups, particularly the elderly.

Impact:

Improved diagnostic capabilities can lead to earlier detection and treatment of LM and LMM.
Optimized surgical planning may improve patient outcomes and reduce recurrence rates.
Exploring alternative treatments can enhance therapeutic options for elderly patients with LM and LMM, balancing efficacy and acceptability.