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The effect of thrombosis-related laboratory values on mortality in COVID-19 infection

Z Ergenc1, H Ergenc, A Öztürk

  • 1Department of Internal Medicine, Yalova State Hospital, Yalova, Turkey. dr.hasanergenc@hotmail.com.

European Review for Medical and Pharmacological Sciences
|April 4, 2023
PubMed

Insights

This study found that D-Dimer levels, but not mean platelet volume (MPV), can help predict the risk of mortality in patients with COVID-19. Early D-Dimer assessment may aid in managing COVID-19 complications.

Area of Science:

  • Medical research
  • Hematology
  • Infectious diseases

Background:

  • COVID-19 is associated with thrombosis in both venous and arterial systems.
  • Understanding thrombosis markers is crucial for managing COVID-19 and its complications.
  • D-Dimer and mean platelet volume (MPV) are indicators related to thrombosis development.

Purpose of the Study:

  • To investigate the potential of MPV and D-Dimer values in determining thrombosis risk and mortality in early-stage COVID-19.
  • To analyze the association between hematological parameters and COVID-19 patient outcomes.

Main Methods:

  • Retrospective analysis of 424 COVID-19 positive patients.
  • Inclusion of demographic and clinical data, including hospitalization duration.
  • Analysis of biochemical, hormonal, and hematological parameters, comparing living and deceased patient groups.

Main Results:

  • White blood cells, neutrophils, and monocytes were significantly lower in the living group compared to the deceased group (p<0.001).
  • No significant difference in MPV values was observed between survivors and deceased patients (p=0.994).
  • D-Dimer levels were significantly higher in deceased patients (median 438 mg/L) than in survivors (median 0.63 mg/L) (p<0.001).

Conclusions:

  • MPV levels did not show a significant relationship with mortality in COVID-19 patients.
  • A significant association was observed between elevated D-Dimer levels and increased mortality risk in COVID-19 patients.
Abstract

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