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Related Concept Videos

Studying the Cytoskeleton01:17

Studying the Cytoskeleton

The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...

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Related Experiment Video

Updated: Jun 2, 2026

Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction
10:37

Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction

Published on: January 16, 2014

Quantifying changes in fibrin fiber network morphology.

Etheresia Pretorius1

  • 1Department of Anatomy, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. resia.pretorius@up.ac.za

Ultrastructural Pathology
|May 17, 2011
PubMed
Summary
This summary is machine-generated.

A simple grid technique quantifies changes in fibrin clot structure. This method analyzes fibrin fiber morphology in micrographs, aiding the study of hemostasis conditions.

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Last Updated: Jun 2, 2026

Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction
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Published on: January 16, 2014

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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

Area of Science:

  • Biochemistry
  • Biophysics
  • Hematology

Background:

  • Blood clotting involves thrombin and fibrinogen interactions, forming a fibrin network.
  • Ultrastructural techniques are used to study fibrin clot morphology.
  • Quantifying changes in fibrin ultrastructure is crucial for understanding hemostasis.

Purpose of the Study:

  • To investigate a grid-based method for quantifying changes in fibrin fiber morphology.
  • To assess the feasibility of this technique for studying hemostasis.

Main Methods:

  • Micrographs of fibrin clots from a healthy donor were analyzed.
  • A grid was overlaid on micrographs (40,000× magnification) to measure morphology.
  • Grid dimensions (0.5 x 0.5 µm blocks) were calibrated using the micrograph scale bar.

Main Results:

  • The donor's fibrin fiber morphology was representative of a typical healthy individual.
  • Percentage changes in fibrin fiber morphology were calculated within 28 µm² grid areas.
  • The technique demonstrated the ability to quantify ultrastructural changes.

Conclusions:

  • An effortless grid technique can quantify changes in fibrin clot ultrastructure.
  • This method offers a statistically sound approach for studying fibrin fiber morphology in hemostasis research.