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Cutaneous adverse reactions to fluoroquinolones
Kanokvalai Kulthanan1, Leena Chularojanamontri, Araya Manapajon
1Department of Dermatology, Faculty of Medicine, Adverse Drug Reaction Center, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Dermatitis : Contact, Atopic, Occupational, Drug
|May 17, 2011
Summary
This study reveals that different fluoroquinolones cause varying types and rates of skin reactions. Some fluoroquinolone generations show potential for cross-reactivity, impacting patient safety.
Area of Science:
- Dermatology
- Pharmacology
- Drug Safety
Background:
- Limited comprehensive studies exist on fluoroquinolone-associated cutaneous adverse drug reactions.
- Previous research has focused broadly on adverse reactions, not specifically skin manifestations.
Purpose of the Study:
- To characterize cutaneous reactions linked to specific fluoroquinolones.
- To investigate cross-sensitivity patterns among different fluoroquinolone classes.
Main Methods:
- Retrospective review of voluntary adverse event reports from January 2004 to December 2008.
- Data sourced from the Adverse Drug Reaction Center, Siriraj Hospital, Thailand.
- Analysis of 166,736 patients treated with fluoroquinolones.
Main Results:
- Overall adverse reaction prevalence was 0.13%, with cutaneous reactions at 0.09%.
- Ciprofloxacin was most frequently implicated (n=93), with maculopapular rash being the most common reaction (39.7%).
- 15.4% of patients with prior fluoroquinolone hypersensitivity showed cross-reactivity potential.
Conclusions:
- Individual fluoroquinolones exhibit distinct patterns and frequencies of cutaneous reactions.
- A potential for cross-reactivity exists between different fluoroquinolone generations.
- These findings highlight the need for careful monitoring of skin reactions and potential cross-reactivity in patients using fluoroquinolones.
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