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Updated: Jun 2, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

[MC1R polymorphisms and facial photoaging].

J Latreille¹, K Ezzedine, A Elfakir

¹CE.R.I.E.S., unité de biométrie et épidémiologie, 20 rue Victor-Noir, Neuilly-sur-Seine, France.

Annales De Dermatologie Et De Venereologie

|May 17, 2011

Summary

Genetic variations in the melanocortin-1 receptor (MC1R) significantly increase the risk of severe facial skin photoaging. The presence of two major diminished function variants is a key risk factor.

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Last Updated: Jun 2, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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Published on: September 7, 2013

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Area of Science:

Genetics
Dermatology
Molecular Biology

Background:

Facial skin photoaging is a significant concern.
The role of genetic factors, particularly MC1R, is increasingly recognized.

Purpose of the Study:

To investigate the association between melanocortin-1 receptor (MC1R) gene variants and the severity of facial skin photoaging.
To determine if MC1R polymorphism influences the degree of photoaging in middle-aged women.

Main Methods:

A cohort of 530 French women (ages 44-70) was analyzed.
Facial photoaging severity was assessed by a dermatologist using Larnier's global scale.
Logistic regression models adjusted for confounders evaluated the impact of MC1R variants on photoaging grades.

Main Results:

35% of participants were wild-type homozygotes, 49% had one MC1R variant, and 15% had two variants.
The presence of two major diminished function MC1R variants was identified as a significant risk factor for severe photoaging (aOR=5.61).

Conclusions:

Genetic variations in the MC1R gene are crucial determinants of severe facial skin photoaging.
MC1R genotype should be considered in understanding individual susceptibility to sun-induced skin aging.