[Paraneoplastic multicentric reticulohistiocytosis]
C Nicol1, G Quereux, J-J Renaut
1Clinique dermatologique, CHU de Nantes, place Alexis-Ricordeau, Nantes cedex 01, France. dr.nicol.christelle@orange.fr
Annales De Dermatologie Et De Venereologie
|May 17, 2011
Summary
Multicentric histiocytosis (MH), a rare skin disorder, can indicate underlying cancer. Early diagnosis and treatment of associated gastric carcinoma led to MH lesion resolution, suggesting a paraneoplastic syndrome.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Multicentric histiocytosis (MH) is a rare histiocytic disorder of unknown cause.
- MH is associated with malignancy in 25% of cases, necessitating thorough cancer screening.
Observation:
- A 74-year-old woman presented with hand papules, nodules, joint pain, and fatigue.
- Dermal biopsy confirmed MH with multinucleated giant cells (CD68+).
- Gastric carcinoma was diagnosed via malignancy screening.
Findings:
- Cutaneous MH lesions resolved weeks after gastrectomy.
- No recurrence of MH or gastric cancer was observed over 7 years.
- Rapid MH lesion resolution post-surgery suggests a paraneoplastic phenomenon.
Implications:
- This case highlights MH as a potential paraneoplastic syndrome, particularly with gastric cancer.
- Routine neoplasia screening is crucial upon MH diagnosis.
- Prompt cancer treatment may lead to MH remission.
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