Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
Global Regulatory Systems01:28

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Bacterial Translocation and Protein Secretion01:26

Bacterial Translocation and Protein Secretion

Bacterial protein secretion involves translocation systems to ensure proteins reach their designated locations, including the plasma membrane, periplasm, outer membrane, or the external environment. These translocation systems are vital for bacterial physiology, supporting processes like membrane assembly, enzymatic activity in the periplasm, and interactions with the external environment. The division of labor between Sec and Tat pathways ensures efficiency in handling proteins with diverse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From leaf to cellulose scaffold: Decellularization and multi-scale characterization of <i>Neolamarckia cadamba</i> leaf for biomedical applications.

Journal of biomaterials applications·2026
Same author

Therapeutic zinc targets dysregulated GC-C signaling and restores ileal defects in a preclinical model of familial diarrheal disease.

American journal of physiology. Gastrointestinal and liver physiology·2026
Same author

GBP1 recruitment to actin-rich pedestals of extracellular Gram-negative bacteria promotes pyroptosis.

The EMBO journal·2026
Same author

Pentraxin-3 as a diagnostic and prognostic biomarker in inflammatory lung diseases.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

Validation of 12-lead Smartphone-based spandan ultra 12L electrocardiogram durations and amplitudes analysis as compared to the standard 12-lead electrocardiogram.

Biomedical physics & engineering express·2026
Same author

Epigenetic regulation of PANoptosis: DNA methylation, histone modifications and non-coding RNAs.

EXCLI journal·2026

Related Experiment Video

Updated: Jun 2, 2026

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
07:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

Signalling mechanisms in Mycobacteria.

Pradip K Chakraborti1, Nishad Matange, Vinay K Nandicoori

  • 1Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India. pradip@imtech.res.in

Tuberculosis (Edinburgh, Scotland)
|May 17, 2011
PubMed
Summary
This summary is machine-generated.

Mycobacteria utilize unique signaling pathways, blending bacterial and eukaryotic mechanisms. Researchers in India have significantly advanced understanding of these complex cellular communication systems.

More Related Videos

Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis
07:32

Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis

Published on: March 28, 2025

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes
08:34

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Published on: September 27, 2018

Related Experiment Videos

Last Updated: Jun 2, 2026

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
07:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis
07:32

Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis

Published on: March 28, 2025

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes
08:34

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Published on: September 27, 2018

Area of Science:

  • Microbiology
  • Cellular Biology
  • Biochemistry

Background:

  • Cellular signal transduction is crucial for all life forms.
  • Mycobacteria possess a diverse array of signaling genes.
  • These bacteria exhibit a mix of prokaryotic and eukaryotic-like signaling components.

Purpose of the Study:

  • To review the contribution of Indian researchers to understanding Mycobacterial signaling.
  • To highlight the identification and characterization of key signaling proteins in Mycobacteria.

Main Methods:

  • Literature review focusing on studies from India.
  • Analysis of identified proteins involved in two-component systems.
  • Examination of proteins related to protein phosphorylation and cyclic nucleotide metabolism.

Main Results:

  • Indian researchers have identified and characterized numerous proteins in Mycobacterial signaling pathways.
  • The study highlights the presence of both bacterial (e.g., histidine-aspartate phosphorelay) and eukaryotic-like signaling components in Mycobacteria.
  • Significant progress has been made in understanding cyclic nucleotide metabolism and protein phosphorylation in these organisms.

Conclusions:

  • Mycobacteria employ sophisticated and hybrid signaling mechanisms.
  • Research from India has been pivotal in elucidating these complex cellular processes.
  • Further investigation into these pathways could reveal novel therapeutic targets.