Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aspirin Eugenol Ester Ameliorates Fatty Liver Hemorrhagic Syndrome in Laying Hens by Reducing Oxidative Stress and Inflammation.

International journal of molecular sciences·2026
Same author

Genomic insights into the admixture history and adaptive evolution of the Zhuang people.

Molecular biology and evolution·2026
Same author

Multivalent nanoparticles activate T-dependent antibody response via antigen presentation by both B cells and dendritic cells.

Cell reports·2026
Same author

The Potential of Landscape Plants <i>Photinia</i> Ă— <i>fraseri</i> and <i>Pittosporum tobira</i> as Refuge for Natural Enemies of Pest Insects in Rice-Wheat Rotation Systems.

Insects·2026
Same author

Widely targeted metabolomics reveals conserved and differential metabolite patterns related to nutritional and bioactive compounds in stems and leaves of three <i>Portulaca oleracea</i> cultivars.

Food chemistry: X·2026
Same author

Association of NEK7 locus variants with distinct palmar crease patterning in Han Chinese.

The Journal of investigative dermatology·2026
Same journal

The scaffolding protein AKAP79/150 shapes innate immune responses to allergen.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

Optineurin restrains IL-17-associated neuroinflammation in trigeminal ganglia to preserve sensory function after ocular HSV-1 infection.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

Crystal structure and immune single-cell atlas provide insights into the functional divergence of type I IFNs in fish.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

Complement C3 deficiency increases the effector and cytotoxic functions of NK cells and suppresses tumor growth.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

FTR85 negatively regulates type I IFN antiviral signaling pathway by promoting K48-linked polyubiquitination of IRF3.

Journal of immunology (Baltimore, Md. : 1950)·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

LIGHT regulates inflamed draining lymph node hypertrophy.

Mingzhao Zhu1, Yajun Yang, Yugang Wang

  • 1Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. zhumz@ibp.ac.cn

Journal of Immunology (Baltimore, Md. : 1950)
|May 17, 2011
PubMed
Summary
This summary is machine-generated.

The immune system

More Related Videos

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
07:45

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

Published on: January 26, 2024

Related Experiment Videos

Last Updated: Jun 2, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
07:45

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

Published on: January 26, 2024

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Lymph node (LN) hypertrophy, an increase in LN cellularity, signals immune responses but its mechanisms are unclear.
  • Understanding LN hypertrophy is crucial for developing effective immune therapies.
  • Identifying key regulators of LN hypertrophy can reveal new therapeutic targets.

Purpose of the Study:

  • To identify novel factors regulating lymph node hypertrophy.
  • To elucidate the role of LIGHT (TNFSF14) in immune responses.
  • To investigate the cellular sources and mechanisms of LIGHT action in lymph node hypertrophy.

Main Methods:

  • Utilized mouse models (wild type and LIGHT(-/-) mice) with CFA immunization.
  • Assessed lymphocyte and dendritic cell migration.
  • Quantified chemokine and addressin expression in skin and LNs.
  • Investigated the role of radioresistant vs. radiosensitive cells in LIGHT-mediated effects.

Main Results:

  • LIGHT (TNFSF14) is essential for LN hypertrophy following CFA immunization.
  • LIGHT regulates lymphocyte influx into LNs and dendritic cell migration from skin.
  • LIGHT deficiency leads to reduced chemokine and addressin expression.
  • LIGHT derived from radioresistant cells, likely Langerhans cells, is critical.

Conclusions:

  • LIGHT is a novel regulator of LN hypertrophy, impacting immune cell trafficking.
  • LIGHT's role in LN hypertrophy is crucial for effective Ag-specific T cell responses.
  • This study reveals a new mechanism for controlling adaptive immunity via LN hypertrophy.