Pediatric vitamin D deficiency in a southwestern luminous climate

Elizabeth Ann Szalay1, Elyce B Tryon, Michael D Pleacher

  • 1Department of Orthopaedics, University of New Mexico School of Medicine, UNM Carrie Tingley Hospital, 1127 University Blvd. NE, Albuquerque, NM 87102, USA. ESzalay@salud.unm.edu

Insights

Even in sunny climates, many children have insufficient vitamin D levels. This study found that 14% of children had vitamin D levels below 20 ng/mL, indicating a need for supplementation.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Nutritional Science

Background:

  • Vitamin D sufficiency is often assumed in sunny climates due to sun exposure.
  • Changing lifestyles may impact vitamin D levels in children.
  • Previous studies highlighted vitamin D deficiency in extreme climates.

Purpose of the Study:

  • To examine vitamin D levels in healthy children residing in a sunny climate.
  • To assess if children with vague musculoskeletal pain have different vitamin D levels compared to healthy controls.

Main Methods:

  • Retrospective chart review of vitamin D levels in children with musculoskeletal pain.
  • Prospective recruitment of healthy children without pain as controls.
  • Analysis of vitamin D levels (ng/mL) in 88 children (42 pain, 46 controls).

Main Results:

  • No significant difference in vitamin D levels between the pain group (29.1 ng/mL) and control group (32.4 ng/mL).
  • Overall, 14% of children had vitamin D levels <20 ng/mL (insufficient).
  • 49% of children had vitamin D levels <30 ng/mL, a potentially desired level.

Conclusions:

  • A sunny climate does not guarantee vitamin D sufficiency in children.
  • A significant percentage of children in this study had insufficient or suboptimal vitamin D levels.
  • Universal vitamin D supplementation is suggested for children, with monitoring for high-risk individuals.
Abstract

Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...