Related Experiment Video
Updated: Jun 2, 2026

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
Published on: September 19, 2025
Dyspnea in mechanically ventilated critically ill patients.
Matthieu Schmidt1, Alexandre Demoule, Andrea Polito
1Assistance Publique-Hôpitaux de Paris, Service de Pneumologie et Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Dyspnea, or difficulty breathing, is common in mechanically ventilated patients and linked to anxiety. Adjusting ventilator settings can help, but unresolved dyspnea may delay extubation.
Area of Science:
- Critical Care Medicine
- Respiratory Physiology
- Patient Comfort
Background:
- Ensuring patient comfort in intensive care units (ICUs) is vital.
- While pain management is well-studied, dyspnea in mechanically ventilated patients remains under-researched.
- Understanding dyspnea is crucial for improving patient outcomes.
Purpose of the Study:
- To determine the prevalence of dyspnea in mechanically ventilated patients.
- To identify clinical factors associated with dyspnea.
- To examine the impact of dyspnea on clinical outcomes, including extubation success.
Main Methods:
- A 6-month prospective observational study was conducted in two university hospital medical ICUs.
- 96 intubated or tracheotomized patients requiring mechanical ventilation for over 24 hours were enrolled.
- Dyspnea was assessed using a yes-no question, visual analog scale, and descriptor choice; pain and anxiety were also measured.
Main Results:
- Nearly half of patients (47%) reported dyspnea, often described as 'air hunger' or 'respiratory effort'.
- Dyspnea was significantly associated with higher anxiety levels (OR 8.84), assist-control ventilation (OR 4.77), and increased heart rate.
- Improving dyspnea by adjusting ventilator settings occurred in 35% of patients, and unresolved dyspnea was linked to less frequent successful extubation within 3 days (17% vs 40%).
Conclusions:
- Dyspnea is a frequent and intense symptom in mechanically ventilated patients.
- A strong correlation exists between dyspnea and anxiety in this population.
- Dyspnea appears responsive to ventilator adjustments and may predict delayed extubation.
Related Concept Videos
Acute Respiratory Failure-III
Acute Respiratory Failure-IV
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Mechanical Ventilation I: Indication and Settings
Alterations in Respiration II
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes include...
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
