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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Chorioamnionitis due to Arcanobacterium haemolyticum

Sonal Saxena1, Charu Aggarwal, Anuradha

  • 1Department of Microbiology, Lady Hardinge Medical College, New Delhi, India.

Journal of Global Infectious Diseases
|May 17, 2011
PubMed

Insights

This case report details chorioamnionitis caused by Arcanobacterium haemolyticum, an uncommon pathogen. Prompt diagnosis and treatment are crucial for managing this serious pregnancy infection.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Microbiology

Background:

  • Chorioamnionitis is a common intra-amniotic infection, typically caused by ascending vaginal flora or hematogenous spread.
  • It poses significant risks for maternal and fetal mortality and morbidity.
  • Early diagnosis and appropriate antibiotic therapy are essential for favorable outcomes.

Observation:

  • A 19-year-old primigravida at 32 weeks gestation presented with symptoms of chorioamnionitis, including fever and vaginal discharge.
  • Arcanobacterium haemolyticum was identified as the causative agent in the amniotic fluid.
  • The patient received a course of gentamicin and metronidazole.

Findings:

  • A healthy male infant weighing 1.9 kg was delivered following induction of labor.
  • The mother experienced an uneventful recovery and was discharged on the ninth postpartum day.
  • Isolation of Arcanobacterium haemolyticum highlights the diverse microbial causes of chorioamnionitis.

Implications:

  • This case underscores the importance of considering unusual pathogens in chorioamnionitis diagnosis.
  • Increased awareness among clinicians and laboratory personnel can prevent misdiagnosis.
  • Timely and accurate identification of causative agents facilitates targeted antimicrobial treatment, improving patient outcomes.
Keywords:
Arcanobacterium haemolyticumChorioamnionitisPremature rupture of membranes

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