Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

New-found link between microbiota and obesity.

World journal of gastrointestinal pathophysiology·2015

Same author

Role of adiponectin and some other factors linking type 2 diabetes mellitus and obesity.

World journal of diabetes·2015

Same author

Effect of different polymers on in vitro and ex vivo permeability of Ofloxacin from its mucoadhesive suspensions.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society·2015

Same author

Role of different biodegradable polymers on the permeability of ciprofloxacin.

Journal of advanced pharmaceutical technology & research·2014

Same author

Preparation and evaluation of three mucoadhesive dosage forms using (99m)Tc-Ofloxacin.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2014

Same author

Qualitative analysis of controlled release ciprofloxacin/carbopol 934 mucoadhesive suspension.

Journal of advanced pharmaceutical technology & research·2011

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Published on: June 9, 2023

Vitamin D as a promising anticancer agent.

Chandra Kanti Chakraborti¹

¹Department of Microbiology, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela, India.

Indian Journal of Pharmacology

|May 17, 2011

Summary

Vitamin D shows promise in preventing and treating cancers like colorectal, prostate, and breast cancer. It works by inhibiting cancer cell growth and promoting cell death, acting as a valuable adjuvant therapy.

Area of Science:

Oncology
Molecular Biology
Nutritional Science

Background:

Vitamin D receptors are present in noncalcemic tissues.
Vitamin D influences growth factor-mediated cellular functions.
Potential role of vitamin D in cancer genesis, progression, and survival is suggested.

Purpose of the Study:

To evaluate the potential of vitamin D in cancer prevention and regression.
To investigate the mechanisms by which vitamin D affects cancer cells.
To explore vitamin D's role as an adjuvant in cancer therapy.

Main Methods:

In vitro and in vivo studies were conducted.
Analysis of vitamin D's interference with growth factor receptor signaling pathways (receptor tyrosine kinases).

Keywords:

Angiogenesis apoptosis cancer cell proliferation vitamin D

More Related Videos

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

Related Experiment Videos

Last Updated: Jun 2, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Published on: June 9, 2023

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

Assessment of vitamin D's effect on gene expression, cell proliferation, angiogenesis, differentiation, and apoptosis.

Main Results:

Optimistic data regarding vitamin D's potential in preventing and regressing colorectal, prostate, and breast cancers.
Vitamin D interferes with receptor tyrosine kinase pathways, modulating transcription and genomic functions.
Vitamin D inhibits cell proliferation and angiogenesis, while facilitating cell differentiation and apoptosis.
Vitamin D upregulates cystatin D, an endogenous protein with antitumor and antimetastatic properties.

Conclusions:

Vitamin D demonstrates significant potential in cancer prevention and as an adjuvant in cancer treatment.
Its mechanisms involve modulating key cellular pathways, inhibiting tumor growth, and promoting cell death.
Further research supports its inclusion in combination chemotherapy regimens for various cancers.