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Related Experiment Video

Updated: Jun 2, 2026

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Published on: August 16, 2012

Field-portable lensfree tomographic microscope.

Serhan O Isikman¹, Waheb Bishara, Uzair Sikora

¹UCLA Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA.

|May 17, 2011

Summary

This summary is machine-generated.

We developed a portable lensfree tomographic microscope for large-volume, high-resolution 3D imaging. This compact device offers a cost-effective solution for advanced imaging in diverse settings.

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Area of Science:

Optical microscopy
Biomedical imaging
Nanotechnology

Background:

Traditional microscopy is often bulky and expensive, limiting its use in field settings.
High-resolution 3D imaging is crucial for understanding biological structures and disease mechanisms.

Purpose of the Study:

To develop a compact, field-portable, lensfree tomographic microscope for on-chip imaging.
To achieve high axial and lateral resolution for large-volume samples.

Main Methods:

Utilized a cost-effective microprocessor-controlled LED array and fiber-optic waveguides for illumination.
Employed sub-pixel shifted hologram recording to generate super-resolved (SR) lensfree holograms.
Reconstructed SR projection holograms over a ±50° angular range for tomographic imaging.

Main Results:

Achieved sectional imaging of a large volume (∼20 mm³) with an axial resolution of <7 micrometers.
Demonstrated the system's capability by imaging micro-beads and a Hymenolepis nana egg.
Validated the compact (∼110 grams) and lightweight design for field portability.

Conclusions:

The developed lensfree tomographic microscope offers a promising tool for telemedicine and high-throughput imaging.
Its portability and cost-effectiveness make it suitable for resource-poor settings.
The technology enables advanced 3D imaging outside traditional laboratory environments.