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Updated: Jun 2, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
Successful therapy to a progressive tumor using monoclonal-antibodies to T-cell regulatory molecules and
B Horvat1, A Rodriguez, E Brewer
1UNIV N CAROLINA,DEPT PERIODONT,CHAPEL HILL,NC 27514. UNIV N CAROLINA,DEPT MICROBIOL IMMUNOL,CHAPEL HILL,NC 27514. YALE UNIV,SCH MED,DEPT PATHOL,NEW HAVEN,CT 06510. YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06510.
Abstract:
Weekly injections of monoclonal antibodies (mAb) to T-cell regulatory molecules, into animals challenged with a progressively growing epithelial cell tumor 3152-PRO, decreased tumor incidence and caused significantly slower tumor growth, compared with animals given identical treatments of control rat mAb. Some of the mAb showed significant synergy with rIL-2 in the successful therapeutic treatment of 3152-PRO. Furthermore, spleen cells from treated mice generated strong tumor-specific cytotoxic activity. The successful elimination of progressively growing 3152-PRO tumor rendered animals specifically resistant to a secondary challenge of 3152-PRO tumor cells, but not to 2237-PRO or 3256-PRO, two other, noncrossreactive tumors.
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